In a new study, researchers found a new potential treatment combination for pancreatic cancer.
The new finding may help benefit people with cancer and save lives in the future.
The research was conducted by researchers from UCLA’s Jonsson Comprehensive Cancer Center.
Pancreatic cancer occurs when cells in the pancreas, which is behind the stomach, begin to multiply out of control and form a mass.
The cancer cells can invade other parts of the body. This cancer often becomes resistant to treatments that work in treating other cancers.
Currently, there is no effective therapy to deal with pancreatic cancer.
In the study, the researchers aimed to understand how the cancer cell pathways work and they hoped to find potential new targets for therapies.
The team first took chloroquine, which is used to treat malaria, and combined it with more than 500 different inhibitors to screen for any interactions that could yield a cancer-fighting effect.
They found a complementary inhibitor called replication stress response inhibitor.
Based on the results, they developed a drug combination. The drug combo uses one drug that inhibits the process that allows cancer cells to survive and another drug that blocks the pathway can cancer use to repair DNA.
The team found the drug combo was promising after testing it on pancreatic cancer cells and mice.
The researchers suggest that their study provides evidence that using chloroquine in combination with an inhibitor could reduce tumor growth in pancreatic cancer.
Their findings help with the understanding of the underlying mechanism of pancreatic cancer and can lead to new treatment strategies for the disease.
This might benefit patients and help improve the prognosis for people with the disease.
It also shows how existing drugs could work and help treat other diseases.
The study is published in the Proceedings of the National Academy of Sciences.
To prevent pancreatic cancer with healthy lifestyle habits, people can do several things:
Prevent type 2 diabetes and obesity. If you have a healthy weight, try to maintain it.
Avoid smoking. Researchers suggest that smoking is the most important avoidable risk factor for pancreatic cancer.
Quitting smoking can help lower the risk of many chronic diseases and increase the quality of life.
Reduce alcohol drinking. Heavy alcohol use can lead to conditions such as chronic pancreatitis and cirrhosis, which may increase pancreatic cancer risk.
Eat a healthy diet. Eating plenty of healthy grains, vegetables, and fish, as well as limiting red meat and sweets, has been shown to lower the risk of pancreatic cancer.
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