In a new study, researchers have identified an exercise-linked hormone that could slow the progression of Alzheimer’s disease.
The findings show that irisin, a hormone that is boosted by exercise, plays an important role in the brain and that Alzheimer patients carry less of the hormone.
This discovery moves scientists one step closer to developing a medication that reproduces the effects of exercise-induced irisin production in the brain.
The study was done by Queen’s University researcher Fernanda De Felice (Psychiatry), along with co-authors from the Federal University of Rio de Janeiro.
In the past few years, researchers from many places around the world have shown that exercise is an effective tool to prevent different forms of dementia such as Alzheimer’s.
This has led to an intense search for specific molecules that are responsible for the protective actions of exercise in the brain.
Because irisin seems to be powerful in rescuing disrupted synapses that allow communication between brain cells and memory formation, it may become a medication to fight memory loss in Alzheimer’s disease.
The new research is important, because curing dementia is one of the greatest current and future health care challenges.
Unfortunately, despite 30 years searching for treatment drugs, there is no effective medication for Alzheimer’s disease.
It is also important to remember that the vast majority of patients with dementia can be disabled due to other age-related illness (e.g. arthritis, heart disease, obesity, visual problems, and depression).
Furthermore, it can be challenging to engage a patient in regular physical activity.
A drug that increases irisin in the brain could be the key.
The team suggests that It is important to keep in mind that Alzheimer’s is a very complex disease and it is truly hard to treat Alzheimer’s patients before irreversible damage occurs in their brains.
This is because when a patient is diagnosed with Alzheimer’s disease, their brain has already been damaged.
Finding new protective routes, such as the identification of an exercise-linked component, may be an optimal strategy to heal the brain before brain cells die and dementia becomes irreversible.
The next step in Dr. De Felice’s research is investigating the most effective way of delivering irisin to the brain.
This research is published in the high-profile publication, Nature Medicine.
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Source: Nature Medicine.
