Bigger brain may mean bigger cancer risk

In a new study, researchers found that bigger brain may mean bigger risks of brain cancer.

It may simply be that having a big brain is itself the cause.

That’s what doctor and Ph.D. candidate Even Hovig Fyllingen at the Norwegian University of Science and Technology (NTNU) has determined with his research colleagues.

Aggressive brain cancer is a rare type of cancer, but once you have it, the chance of survival is relatively low.

Lifestyle matters less

For some types of cancer, lifestyle makes a big difference.

People who smoke have a greater risk of lung cancer than non-smokers, for example. A person’s lifestyle matters less for brain tumor development.

A large brain means more brain cells. And the more cells you have, the more cell divisions that can go wrong and create mutations that lead to cancer.

Big organs, bigger risk

Several studies have shown that the size of different organs is an important factor in cancer development.

For example, women with larger breasts have a greater risk of breast cancer. We wanted to check if this was also the case for brain tumors.

To tackle the question, the researchers relied on material from the Nord-Trøndelag Health Study (HUNT).

The study comprises health data and blood samples that have been collected in multiple waves of data gathering from thousands of Norwegians in the Nord-Trøndelag county region.

The purpose of the study is to find out why some individuals become ill while others stay healthy, what affects our health and how our health affects our lives.

The team used the third version of the survey, called HUNT3, and compared it to St. Olavs Hospital’s neurosurgery database.

They extracted data on everyone who had been operated on for high-grade gliomas (brain tumors) between 2007 and 2015 and compared their data with healthy controls from the HUNT study.

The researchers used MRI scans to measure the size of the brain. Then 3-D models were made from them so that the intracranial brain volume could be measured in milliliters.

Mostly men who get brain tumors

The study also shows that more men than women develop brain tumors.

Men have a larger brain than women because men’s bodies are generally larger.

It doesn’t mean that men are smarter, but men need to have more brain cells to control a large body.

This is also the case with animals. In bigger bodies, organs like the heart, lungs, and brain are also bigger.

Yet it turns out that women with big brains have a greater risk of developing brain tumors compared to men with big brains.

Seventy percent more men than women develop brain tumors, but when the team corrected for head size, it’s no longer beneficial to be female.

Women with large brains are particularly susceptible. Researchers currently have no explanation of this.

The study is published in the Neuro-Oncology.

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Source: Norwegian University of Science and Technology.