Proton pump inhibitors (PPIs) are widely used in the U.S. to treat heartburn, acid reflux, and gastroesophageal reflux disease (GERD). Medications like Prilosec, Nexium, and Prevacid provide relief for millions, with around 10% of adults taking them daily.
However, new research from the University of California San Diego raises serious concerns about the long-term effects of these medications, particularly on kidney health.
Study Findings: PPIs and Kidney Disease
Researchers analyzed data from the FAERS database, which contains over 10 million reports of medication side effects. The study focused on 43,000 patients who exclusively used PPIs and compared them with 8,000 patients who took histamine-2 receptor blockers (such as Zantac or Pepcid) without any other medications.
The results were concerning:
- 5.6% of PPI users reported kidney-related issues, compared to just 0.7% in the histamine-2 blocker group.
- PPI users were 28.4 times more likely to report chronic kidney disease than the control group.
- Risks of acute kidney injury, end-stage kidney disease, and electrolyte imbalances were also significantly higher among PPI users.
Not the First Warning
This isn’t the first study to highlight potential dangers of PPIs. A 2017 study from the same university suggested that these drugs might also increase the risk of chronic liver disease. The growing body of evidence calls for caution in how these medications are prescribed and used.
Balancing Benefits and Risks
PPIs are effective in reducing stomach acid and preventing damage from acid reflux, but this study emphasizes the need for careful use, especially for people at risk of kidney disease. Doctors are encouraged to weigh the benefits and risks before prescribing PPIs, particularly for long-term use.
For patients, it’s essential to stay informed. If you take PPIs regularly, consider discussing alternatives or monitoring your kidney health with your doctor. Histamine-2 blockers, lifestyle changes, or dietary adjustments may offer safer long-term solutions for managing acid-related conditions.
Looking Ahead
Published in Scientific Reports by Ruben Abagyan and his team, this study is a significant step toward ensuring safer use of PPIs. Ongoing research is crucial to fully understanding the long-term impact of these widely used drugs. In the meantime, both doctors and patients should remain aware of the potential risks and make informed decisions about heartburn treatment.
Copyright © 2025 Knowridge Science Report. All rights reserved.
