According to a new study published in Aging, the drug metformin might reduce the risk of delirium and mortality in patients with diabetes.
The study, titled “The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study,” was carried out by researchers from Stanford University School of Medicine, the University of Iowa Carver College of Medicine, the University of Iowa College of Public Health, and Tottori University Faculty of Medicine.
Study Details and Findings
The researchers aimed to investigate the relationship between diabetes mellitus (DM) and delirium risk, focusing specifically on the influence of metformin.
Metformin is a common medication used in the treatment of type 2 diabetes and has previously been reported to improve age-related disorders, including dementia, and to lower mortality.
For their retrospective cohort study, the team analyzed data from 1,404 previously recruited subjects.
They divided these subjects into two categories: a group of 242 patients with type 2 diabetes who did not use metformin and a group of 264 patients with diabetes who did use metformin.
They found that the prevalence of delirium was 36.0% in the group without metformin, and 29.2% in the group with metformin.
After controlling for confounding factors, a history of metformin use was found to lower the risk of delirium in patients with diabetes.
Furthermore, the researchers discovered that the three-year mortality rate was higher in the group without metformin (with a survival rate of 0.595) than in the group with metformin (with a survival rate of 0.695).
After adjustment for confounding factors, a history of metformin use was associated with a decreased risk of three-year mortality.
Based on their findings, the researchers concluded that metformin use might lower the risk of delirium and mortality in patients with diabetes.
They believe that their study shows the potential benefit of metformin in reducing the risk of delirium and mortality in patients with diabetes mellitus.
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The study was published in Aging.
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