In a study from Stanford University and elsewhere, scientists found diabetes drug metformin can help reduce delirium risk and mortality.
Delirium is a serious change in mental abilities. It results in confused thinking and a lack of awareness of someone’s surroundings.
The disorder usually comes on fast — within hours or a few days. Delirium can often be traced to one or more factors.
Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality.
This study aimed to examine whether metformin use lowers delirium risk, as well as long-term mortality.
In the study, researchers analyzed 1,404 previously recruited people.
The link between metformin use and delirium, and the link between metformin use and 3-year death were examined.
The team hypothesized that a history of metformin use is associated with a lower risk for delirium.
They were also interested in testing if the history of metformin use can alter one of the most important patient outcomes, mortality.
In total, 242 people were categorized into a type 2 diabetes-without-metformin group, and 264 people were categorized into a type 2 diabetes-with-metformin group.
Prevalence of delirium was 36.0% in the diabetes-without-metformin group, and 29.2% in the diabetes-with-metformin group.
The team found a history of metformin use reduced the risk of delirium in patients with type 2 diabetes after controlling for confounding factors.
The researchers also found the 3-year death risk in the diabetes-without-metformin group was higher than in the diabetes-with-metformin.
A history of metformin use decreased the risk of 3-year death risk after adjustment for confounding factors.
Based on the findings, the researchers concluded that metformin use may lower the risk of delirium and mortality in people with type 2 diabetes.
If you care about diabetes, please read studies about leading cause of death in type 2 diabetes, and if you have diabetes, coffee and green tea may help you live longer.
For more information about diabetes, please see recent studies about Keto diet could help control body weight, blood sugar in type 2 diabetes and results showing that blueberries strongly benefit people with metabolic syndrome.
The study was conducted by Takehiko Yamanashi et al and published in Aging.
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