Scientists from nference and Mayo Clinic found that the third dose of the COVID-19 mRNA vaccine is safe.
The research is published in JAMA Network Open and was conducted by Michiel J.M. Niesen et al.
In the study, the team evaluated the safety of third-dose vaccination with U.S. Food and Drug Administration–approved COVID-19 mRNA vaccines.
Electronic health record data (December 2020 to October 2021) were used to identify 47,999 individuals receiving three-dose COVID-19 mRNA vaccines.
The team found that reporting of severe adverse events remained low after the third vaccine dose, with rates of pericarditis (heart swelling, 0.01 percent), anaphylaxis (severe allergy, 0 percent), myocarditis (heart inflammation, 0 percent), and cerebral venous sinus thrombosis (no individuals) consistent with results from earlier studies.
Compared to the second dose, there are more individuals reported low-severity adverse events after the third dose, including fatigue, lymphadenopathy, nausea, headache, arthralgia, myalgia, diarrhea, fever, vomiting, and chills.
This study provides further evidence that third-dose vaccination with the same type of COVID-19 mRNA vaccine as used in the primary series is linked to safe outcomes.
Together with previous studies of the safety and effectiveness associated with booster doses, the current study suggests that third-dose mRNA COVID-19 vaccination may be appropriate for at-risk people.
If you care about COVID, please read studies about people who are more likely to get severe COVID-19 after vaccination, and findings of vitamin D deficiency linked to severe COVID-19 and death.
For more information about COVID, please see recent studies about drug that can offer much-needed COVID-19 protection, and results showing scientists find new antibody treatment for COVID-19.
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