In a new study, researchers found that even short, single antibiotic drugs early in life may increase the risk of inflammatory bowel disease (IBD) later in life.
The finding provides further evidence that the use of antibiotics in children under 1 year old disrupts the intestinal microbiota—the trillions of beneficial microorganisms that live in and on our bodies—that play a crucial role in the healthy maturation of the immune system and the prevention of diseases, such as inflammatory bowel disease and type 1 diabetes.
The study was conducted by Rutgers researchers.
The team says the study provides experimental evidence strengthening the idea that the associations of antibiotic exposures to the later development of disease in human children are more than correlations, but that they are actually playing roles in the disease causation.
To determine if the increased disease risk was due to the disruption of the microbiome from antibiotics, the researchers studied the effects of exposure to dextran sulfate sodium, a chemical known to injure the colon, both in mice that received antibiotics and in mice that had perturbed microbial contents transplanted into their intestines versus a control group.
They found that the mice that received either the antibiotics themselves or received the antibiotic-perturbed microbiome had significantly worse colitis, showing that exposure to antibiotics changed the microbiome, altered the immune response in the colon, and worsened the experimental colitis.
The study continues the team’s work on the hypothesis that disrupting the early life gut microbiome, especially by antibiotics and C-section, is one of the factors driving modern epidemics.
One author of the study is Martin Blaser, director of the Rutgers Center for Advanced Biotechnology and Medicine.
The study is published in Genome Medicine.
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