In a new study, researchers found that artificial intelligence (AI) holds promise for enabling earlier detection of pancreatic cancer, which is crucial to saving lives.
The research was conducted by a team at the London School of Hygiene & Tropical Medicine.
Overall, 12 in every 100,000 people develop pancreatic cancer. This means that screening everyone would be inefficient and would expose many people to unnecessary tests and potential side-effects.
Between 70-80% of patients are diagnosed at an advanced stage when it is too late for curative treatment and five years after diagnosis, just 6% of patients have survived.
Screening helps identify cancer early, when treatments are most effective, thus improving survival.
There are two main requirements for screening. First, a screening test that is easy to perform and has few side-effects.
Second, a defined group that would benefit most from screening because they are at higher risk. For example, breast cancer screening involves mammography in women aged 50 to 71 years.
In the study, the team says AI could be the desperately needed answer to define a group of higher-risk individuals that would benefit from screening, especially as recently some promising results have indicated that non-invasive tests for pancreatic cancer may soon be available.
It is known that patients who develop pancreatic cancer consult their general practitioner (GP) with non-specific symptoms such as gastrointestinal problems or back pain more frequently in the months and years prior to diagnosis compared with their peers who do not develop pancreatic cancer.
Individually, these symptoms are unlikely to trigger further investigations for cancer.
The researchers came up with the idea that AI could find a combination of these non-specific symptoms that are linked with a higher risk of contracting the disease, which would be difficult to spot by GPs.
This preliminary study used electronic health records from GP practices in the UK. The analysis included 1,378 patients aged 15-99 years diagnosed with pancreatic cancer in 2005 to 2010.
Each patient was matched by age and sex to four people who did not get pancreatic cancer. Information on symptoms, diseases, and medications in the two years prior to diagnosis were used to create a model predicting who would develop pancreatic cancer.
The pilot study found that in people under 60 years of age, the model could predict who was at higher risk of pancreatic cancer up to 20 months before diagnosis.
The model estimated that around 1,500 tests need to be performed to save one life from pancreatic cancer.
It also showed that AI holds the potential to narrow down the number of people we need to screen.
The team says using AI to identify people at high risk of pancreatic cancer up to 20 months earlier could make the difference between life and death.
This should be enough time to screen for pancreatic cancer, then proceed with diagnosis and treatment in patients with a positive screening test.
Early diagnosis in pancreatic cancer gives the highest chance of cure.
One author of the study is Dr. Ananya Malhotra, a research fellow in statistics, London School of Hygiene & Tropical Medicine.
The study was presented at the ESMO World Congress on Gastrointestinal Cancer.
Copyright © 2020 Knowridge Science Report. All rights reserved.
