In a new study, researchers found that vitamin D can determine severity in COVID-19, and they are calling on the government in Ireland to change recommendations for vitamin D supplements.
The study highlights the association between vitamin D levels and mortality from COVID-19.
The research was conducted by a team from Trinity College Dublin and elsewhere.
The team analyzed all European adult population studies, completed since 1999, which measured vitamin D and compared vitamin D and death rates from COVID-19.
Vitamin D is produced in the skin from UVB sunlight exposure and is transported to the liver and then the kidney where it is changed into an active hormone that increases calcium transport from food in the gut and ensures calcium is adequate to keep the skeleton strong and free of osteoporosis.
But vitamin D can also support the immune system through a number of immune pathways involved in fighting SARS2COV. Many recent studies confirm the pivotal role of vitamin D in viral infections.
This study shows that counter-intuitively, countries at a lower latitude and typically sunny countries, such as Spain and Northern Italy, had low concentrations of vitamin D and high rates of vitamin D deficiency.
These countries also experienced the highest infection and death rates in Europe.
The northern latitude countries of Norway, Finland, and Sweden, have higher vitamin D levels despite less UVB sunlight exposure because supplementation and fortification of foods are more common.
These Nordic countries have lower COVID-19 infection and death rates. The correlation between low vitamin D levels and death from COVID-19 is very strong.
The authors say that, whereas optimizing vitamin D levels will certainly benefit bone and muscle health, the data suggests that it is also likely to reduce serious COVID-19 complications.
This may be because vitamin D is important in the regulation and suppression of the inflammatory cytokine response, which causes the severe consequences of COVID-19 and ‘acute respiratory distress syndrome’ associated with ventilation and death.
One author of the study is Professor Rose Anne Kenny, School of Medicine.
The study is published in the Irish Medical Journal.
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