Type 2 diabetes is a common health problem where the body has trouble using or making enough insulin. This leads to high blood sugar levels, which can cause serious health issues if not controlled.
Metformin is often the first medicine doctors give to manage Type 2 diabetes, but for many people, it stops working as well over time.
Now, researchers at Thomas Jefferson University have found a better treatment option. They discovered that combining two other diabetes medicines—dapagliflozin and exenatide—helps control blood sugar more effectively and keeps working well for a longer time.
The study involved 695 adults with Type 2 diabetes whose blood sugar was not under control with metformin alone. These participants were divided into three groups.
One group got weekly injections of exenatide with their metformin. Another group took daily dapagliflozin pills with metformin. The third group used both dapagliflozin and exenatide along with metformin.
The results showed that the people who took both medicines together had better blood sugar control than those who took only one. Even after two years, the benefits of the combination treatment remained strong.
The reason this combination works so well is that each medicine helps in a different way. Dapagliflozin helps the kidneys remove extra sugar from the body through urine. Exenatide helps the body make more insulin after eating, lowers sugar production in the liver, slows how fast food leaves the stomach, and helps people feel full so they eat less.
By working together, these two medicines not only improve blood sugar levels, but also help people lose weight and lower their blood pressure. These are important benefits for people with diabetes.
The study also showed that this combination treatment is safe. There were no unexpected health problems during the two years of the study. This makes it a reliable option for people who need more help than metformin can provide on its own.
The research was led by Dr. Serge Jabbour and published in the journal Diabetes Care. He said the findings are important for people with Type 2 diabetes who are struggling to keep their blood sugar in check.
This drug combo gives doctors and patients a new way to manage diabetes over the long term. It offers stable blood sugar control, helps with weight loss, and lowers blood pressure—all without causing new health risks.
For anyone with Type 2 diabetes who finds that metformin is no longer enough, this treatment could be a helpful next step. It’s a promising option that could lead to better health and a better quality of life.
If you care about diabetes, please read studies about This drug combo can treat type 2 diabetes in the long run effectively and findings of Eating fewer than 3 meals a day may help reduce risk of type 2 diabetes and obesity.
For more information about diabetes, please read studies about How to choosing the right fruits for type 2 diabetes and findings of New higher dose diabetes drug promises better blood sugar control and weight loss.
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