Doctors from around the world joined forces to study a medicine for people with type 2 diabetes.
This big study took place in 14 countries at 177 different locations. The main leader of the study was Dr. Vanita R. Aroda from a hospital in Boston.
The study focused on people who had high blood sugar levels. These levels were measured using a test called HbA1c. The participants chosen had HbA1c levels between 8.0 and 10.5 percent. They were also taking one to three pills a day to lower their blood sugar.
The researchers tested a medicine called semaglutide. People in the study took this medicine once a day in one of three doses: 14 mg, 25 mg, or 50 mg. They continued this treatment for 68 weeks. The main goal was to see how much the medicine could lower their HbA1c levels in one year.
After one year, the results were clear. All three doses of semaglutide helped lower blood sugar levels, but the higher doses—25 mg and 50 mg—were more effective than the 14 mg dose. The higher the dose, the better the result.
Some people did experience side effects, mostly stomach issues like nausea. These side effects were more common in the higher dose groups but were generally mild.
In simple terms, the study showed that for people with type 2 diabetes, the 25 mg and 50 mg doses of semaglutide helped lower blood sugar more than the 14 mg dose. These doses also helped people lose some weight.
However, it’s important to be aware that the higher doses may cause more stomach problems in some people.
This research gives doctors more information about how to help people with type 2 diabetes manage their blood sugar. It also shows that higher doses of semaglutide might offer extra benefits.
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The study was published in The Lancet.
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