Type 2 diabetes is a widespread condition where the body struggles to use or produce insulin effectively, leading to high blood sugar levels.
For many, managing this condition starts with a medication called metformin. However, over time, metformin may not work as well, and additional treatments are often needed.
Researchers at Thomas Jefferson University have found a promising solution: combining two medications, dapagliflozin and exenatide. This combination not only improves blood sugar control but also maintains its effectiveness over time.
This discovery comes from a large study involving 695 adults with Type 2 diabetes whose blood sugar levels were not well controlled with metformin alone.
Participants in the study were divided into three groups. One group received weekly injections of exenatide with metformin, another took daily dapagliflozin pills with metformin, and the third used both medications together.
Over the two-year study, the group on the combination therapy showed better and more sustained blood sugar control compared to those using just one additional drug.
Each medication in this combination plays a unique role. Dapagliflozin helps the kidneys remove excess sugar from the body through urine.
Exenatide, on the other hand, increases insulin release after meals, reduces sugar production in the liver, slows the digestion of food, and helps people feel full for longer. Together, these medications provide a powerful approach to controlling blood sugar.
The benefits of this combination go beyond blood sugar control. The treatment
also promotes weight loss and lowers blood pressure, addressing two common concerns for people with Type 2 diabetes. This makes it a comprehensive option for managing the condition and improving overall health.
Importantly, the study confirmed that this dual therapy is safe. Participants experienced no unexpected health issues during the two years of treatment. This adds to the appeal of the dapagliflozin and exenatide combination as a reliable long-term option for diabetes management.
Led by Dr. Serge Jabbour, the research was published in the journal Diabetes Care. Dr. Jabbour emphasized the significance of these findings for future diabetes treatment, particularly for patients who struggle to control their blood sugar with metformin alone.
For people managing Type 2 diabetes, this combination offers a new way to maintain stable blood sugar levels, lose weight, and reduce blood pressure over an extended period.
Its effectiveness and safety make it a compelling choice for those whose diabetes has become more challenging to control.
This breakthrough highlights the importance of personalized treatment strategies in diabetes care. By combining these two medications, doctors can offer patients a solution that not only works but also sustains its benefits, improving quality of life and reducing the risk of complications.
If you care about diabetes, please read studies about bananas and diabetes, and honey could help control blood sugar.
For more health information, please see recent studies about Vitamin D that may reduce dangerous complications in diabetes and results showing plant-based protein foods may help reverse type 2 diabetes.
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