People taking medications for high blood pressure may need to think twice before using ibuprofen, a common over-the-counter pain reliever.
A study from the University of Waterloo found that combining ibuprofen with two common high blood pressure drugs—diuretics and renin-angiotensin system (RAS) inhibitors—could lead to serious kidney problems.
Diuretics and RAS inhibitors are often prescribed together to manage hypertension. Diuretics help the body release excess water, reducing blood pressure, while RAS inhibitors work to relax blood vessels. These drugs are widely used and come in various brand names.
Ibuprofen, a non-prescription painkiller, is popular for relieving headaches, muscle aches, and other pain. However, the study highlights that combining it with these blood pressure medications can be risky for certain individuals.
Using computer-simulated drug trials, the researchers modeled how these three drugs interact in the body, focusing on their effects on the kidneys.
They discovered that in some medical conditions, the combination could cause acute kidney injury—a condition where the kidneys suddenly stop working properly. In some cases, this damage could become permanent.
The problem arises from how these drugs affect the kidneys. Diuretics can cause dehydration by reducing the body’s water levels. When combined with RAS inhibitors and ibuprofen, this creates a “triple whammy” effect, putting extra strain on the kidneys and increasing the risk of harm.
The researchers emphasize that not everyone taking this drug combination will experience kidney problems. However, the study shows a clear risk, particularly for people with certain health profiles.
For this reason, people taking diuretics and RAS inhibitors should be cautious when considering painkillers like ibuprofen.
If pain relief is needed, acetaminophen may be a safer option for those on high blood pressure medications. Unlike ibuprofen, acetaminophen does not pose the same risks to kidney function when combined with these drugs.
The study, led by Anita Layton, underscores the importance of being aware of drug interactions, even with over-the-counter medications.
It serves as a reminder for people with high blood pressure to consult their healthcare provider before taking pain relievers like ibuprofen, especially if they are on diuretics and RAS inhibitors.
By being cautious, individuals can avoid potential kidney damage and ensure their treatment plan remains safe and effective.
If you care about blood pressure, please read studies about blood pressure drug that may increase risk of sudden cardiac arrest, and these teas could help reduce high blood pressure.
For more information about health, please see recent studies about nutrient that could strongly lower high blood pressure, and results showing this novel antioxidant may help reverse blood vessels aging by 20 years.
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