Researchers at the University of Waterloo have found that combining a common over-the-counter painkiller, ibuprofen, with certain blood pressure medications could lead to serious kidney problems for some people.
This discovery is important for those managing high blood pressure who might not be aware of the potential risks.
The study specifically focused on people taking both a diuretic and a renin-angiotensin system (RSA) inhibitor, which are commonly prescribed together to control high blood pressure.
These medications are sold under various brand names and work by helping the body expel excess water and relaxing blood vessels to lower blood pressure. However, taking these drugs together with ibuprofen can be risky.
Ibuprofen is a popular painkiller found in many brands available at pharmacies and stores. It’s often used to relieve pain, reduce fever, and decrease inflammation. Many people reach for it without much thought, especially for everyday aches and pains.
However, this study reveals that people using blood pressure medications like diuretics and RSA inhibitors should be careful with ibuprofen.
The research team, led by Anita Layton, used computer simulations to model how these three drugs interact in the body and affect the kidneys.
They discovered that the combination of a diuretic, RSA inhibitor, and ibuprofen can create a dangerous situation for the kidneys, referred to as a “triple whammy” effect.
In some cases, this combination can lead to acute kidney injury, which is a sudden decrease in kidney function. While not everyone taking these medications will experience problems, the researchers warn that the risk is real.
One key issue is dehydration, which diuretics can cause by making the body expel excess water. Dehydration is a major risk factor for acute kidney injury, and combining a diuretic with ibuprofen, which reduces blood flow to the kidneys, can put extra stress on the organs.
RSA inhibitors, which relax blood vessels to lower blood pressure, also affect kidney function. Together, these three drugs can significantly impact kidney health in some individuals.
For people taking these blood pressure medications who need pain relief, the researchers suggest considering acetaminophen as a safer alternative. Acetaminophen is also commonly available and can help with pain relief without the same risks to kidney health.
The study highlights the importance of being cautious when using medications together, especially over-the-counter drugs like ibuprofen that are easily accessible. It’s a reminder that even common medications can have serious effects when combined with other treatments.
This research offers valuable guidance for doctors and patients managing high blood pressure. It encourages healthcare providers to inform their patients about the risks and to suggest safer pain relief options when necessary.
For patients, it underscores the importance of discussing all medications with their doctor, including over-the-counter drugs.
By being aware of these potential risks, individuals can make informed choices about their medications and protect their kidney health.
If you care about high blood pressure, please read studies that early time-restricted eating could help improve blood pressure, and coconut sugar could help reduce blood pressure and artery stiffness.
For more information about blood pressure, please see recent studies about added sugar in your diet linked to higher blood pressure, and results showing plant-based foods could benefit people with high blood pressure.
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