Widely used drugs linked to deadly heart disease in people with type 2 diabetes

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When we discuss heart health for people with type 2 diabetes, the conversation often goes beyond the typical advice of improving diet and exercise.

A recent study presented at the European Association for the Study of Diabetes (EASD) Annual Meeting in Hamburg, Germany, has brought attention to some surprising factors that might increase the risk of sudden cardiac arrest (SCA).

SCA occurs when the heart unexpectedly stops pumping blood, a life-threatening condition that accounts for a significant portion of heart-related deaths globally, particularly in wealthier countries.

Understanding SCA is essential, especially for people living with type 2 diabetes, who already face twice the risk of experiencing this condition compared to those without diabetes.

For individuals with diabetes, identifying additional risk factors is crucial, even if they don’t have a history of heart disease.

The Study: Investigating Risk Factors

A team led by Peter Harms from Amsterdam UMC in the Netherlands conducted a study that focused on individuals with type 2 diabetes living in the region of Noord-Holland.

The researchers analyzed the medical records of 3,919 people with type 2 diabetes, 689 of whom had experienced sudden cardiac arrest between 2010 and 2019.

By comparing the medical histories of these individuals with those of a similar group who had not experienced SCA, the researchers found some key factors that seemed to increase the risk of this heart condition.

Over the five years leading up to each SCA case, the team looked at clinical measurements and medication use, which revealed important connections.

Medications and Heart Risk

One of the most striking findings was the link between certain medications and an increased risk of sudden cardiac arrest.

The study highlighted several types of drugs, including some commonly used antibiotics and antipsychotic medications, as well as prokinetics, which are often prescribed for gastrointestinal issues like nausea.

These drugs, known to prolong the heart’s QT interval (the time it takes for the heart to reset between beats), were associated with a higher risk of SCA. Examples of such medications include the antibiotic macrolides and the antipsychotic drug haloperidol.

These medications can affect the electrical system of the heart, making it more vulnerable to problems like sudden cardiac arrest.

While these drugs are essential for managing certain conditions, their potential side effects on heart health need careful consideration, particularly in people with type 2 diabetes.

Unexpected Risk Factors: Low Blood Sugar and Kidney Issues

Another surprising discovery from the study was that low fasting blood sugar levels, often seen as a sign of good blood sugar control, were linked to a 150% increase in the risk of SCA in people without a history of heart disease.

This finding challenges the common assumption that stricter control of blood sugar always leads to better health outcomes.

In addition, the study found that for those with existing heart conditions, factors like albuminuria (a condition where protein is present in the urine, often indicating kidney problems) and heart failure were strongly associated with an increased risk of sudden cardiac arrest.

This suggests that the presence of kidney-related issues can further complicate heart health in people with diabetes.

What Does This Mean for People with Type 2 Diabetes?

If you have type 2 diabetes, these findings highlight the importance of discussing your overall health with your doctor, especially if you are taking medications that could impact your heart.

While managing your blood sugar is crucial, this study suggests that focusing solely on lowering blood sugar levels may not always be the best approach, particularly if it leads to very low blood sugar levels.

It’s also important to review the medications you are taking with your healthcare provider. Certain drugs, while necessary for treating specific conditions, may increase your risk of heart-related problems.

Regular kidney and heart function tests can help detect early signs of trouble, allowing for timely adjustments to your treatment plan.

A Widened Perspective on Diabetes Care

For doctors, this research offers new insights into the management of diabetes.

While controlling blood sugar, blood pressure, and cholesterol levels remain important, it’s equally critical to be aware of other, less obvious risks, such as low fasting glucose and the use of QTc-prolonging medications.

This more comprehensive approach to managing diabetes can help protect against sudden cardiac arrest and improve long-term heart health.

In conclusion, this study broadens our understanding of the factors that contribute to sudden cardiac arrest in people with type 2 diabetes.

By paying attention to both traditional and unexpected risk factors, doctors and patients can work together to develop treatment plans that not only address immediate health concerns but also safeguard long-term heart health.

If you care about diabetes, please read studies that pomace olive oil could help lower blood cholesterol, and honey could help control blood sugar.

For more information about health, please see recent studies that blueberries strongly benefit people with metabolic syndrome, and results showing eggs in a plant-based diet may benefit people with type 2 diabetes.

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