For patients with type 2 diabetes mellitus (T2DM) who also have tobacco use disorder (TUD), a new study suggests that using semaglutide is linked to a lower risk of TUD-related health issues compared to other antidiabetes medications.
This finding was published online on July 30 in the Annals of Internal Medicine.
Researchers led by William Wang from Case Western Reserve University School of Medicine in Cleveland conducted the study.
They examined the effects of semaglutide on TUD-related health care measures in patients with both T2DM and TUD.
The study simulated seven different target trials among eligible patients, comparing new semaglutide use with seven other antidiabetes medications. The analysis included 222,942 new users of antidiabetes medications, among whom 5,967 were new users of semaglutide.
The results showed that semaglutide users had a significantly lower risk of medical encounters for TUD diagnosis compared to users of other antidiabetes medications.
The strongest association was observed when comparing semaglutide with insulins (hazard ratio, 0.68), and the weakest, but still significant, association was seen when comparing semaglutide with other glucagon-like peptide 1 receptor agonists (hazard ratio, 0.88).
Additionally, patients on semaglutide were less likely to receive prescriptions for smoking cessation medications or undergo counseling for smoking cessation. These findings were consistent regardless of whether the patients had a diagnosis of obesity.
The authors of the study caution that while the results suggest semaglutide might help with smoking cessation, there are limitations to the study. Therefore, the findings should not be taken as a justification for using semaglutide off-label for smoking cessation.
In summary, this study indicates that semaglutide could offer additional benefits for patients managing both type 2 diabetes and tobacco use disorder, potentially reducing the risk of TUD-related health issues. However, further research is needed to confirm these benefits and guide clinical practice.
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The research findings can be found in the Annals of Internal Medicine.
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