Some drugs may trigger sudden cardiac arrest in people with type 2 diabetes

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At the Annual Meeting of the European Association for the Study of Diabetes in Hamburg, Germany, new insights emerged, highlighting the increased risk of sudden cardiac arrest (SCA) among individuals with type 2 diabetes (T2D).

This condition, where the heart unexpectedly stops beating, is a leading cause of death worldwide, especially in developed countries.

It’s particularly concerning for those with T2D, as they’re at double the risk compared to the general population.

The research team, led by Peter Harms from Amsterdam UMC, conducted a detailed study involving 3,919 T2D patients to identify risk factors visible in general practitioner (GP) records that could predict the likelihood of experiencing an SCA.

Among this group, 689 had suffered an SCA. These individuals were matched with 3,230 controls—patients who had not experienced SCA—based on age, sex, and GP practice, to draw meaningful comparisons.

The study revealed several factors that significantly increase the risk of SCA in people with diabetes.

These included a history of heart rhythm problems, unclear smoking status, the use of insulin, and taking certain medications known to prolong the QTc interval (a heart rhythm measurement on an electrocardiogram) like prokinetics.

For patients with a history of cardiovascular disease, the presence of moderate to severe kidney damage, heart failure, and other conditions were strong indicators of SCA risk.

Interestingly, the research pointed out that not only conventional cardiovascular risks, such as high blood pressure, but also lower fasting blood sugar levels and the use of specific antipsychotic and antibiotic medications could elevate the risk of SCA.

This is particularly noteworthy because the dangers of overly strict blood sugar control and the prescription of these common medications may not be widely recognized among GPs.

The implications of these findings are significant. They highlight the need for a more nuanced approach to managing the health of individuals with T2D, especially when it comes to controlling blood sugar and prescribing certain medications.

The study calls for heightened awareness among GPs about the complex interplay of factors that could lead to SCA in diabetic patients.

By understanding these risks better, healthcare providers can tailor their treatment plans more effectively, potentially preventing the devastating occurrence of sudden cardiac arrest in this vulnerable population.

This research is a crucial step forward in understanding and mitigating the risks associated with T2D. It serves as a reminder of the importance of personalized healthcare, urging both patients and doctors to consider the broader implications of diabetes management strategies on heart health.

If you care about heart health, please read studies that yogurt may help lower the death risks in heart disease, and coconut sugar could help reduce artery stiffness.

For more information about health, please see recent studies that Vitamin D deficiency can increase heart disease risk, and results showing vitamin B6 linked to lower death risk in heart disease.

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