These diabetes drugs can reduce kidney stone risk

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In an important development for people with type 2 diabetes, recent research has found a potential benefit of certain diabetes medications in reducing the risk of kidney stones.

This study, led by a team from Mass General Brigham, is very important given the increasing rates of kidney stones in the United States and globally.

Published in JAMA Internal Medicine, the research involved collaboration between Brigham and Women’s Hospital and Massachusetts General Hospital.

The team focused on data from three extensive nationwide patient databases, specifically targeting adults with type 2 diabetes in routine clinical settings.

The study included a sample of 716,406 individuals who had started on one of three classes of diabetes medications: sodium-glucose cotransporter 2 (SGLT2) inhibitors, GLP1 receptor agonists, or dipeptidyl peptidase 4 (DPP4) inhibitors.

The findings showed a strong link between the use of SGLT2 inhibitors and a reduced risk of developing kidney stones.

Patients who began taking SGLT2 inhibitors had a 30% lower risk of kidney stones compared to those on GLP1 agonists, and about a 25% lower risk than those taking DPP4 inhibitors.

This lower risk was observed consistently across various demographics, including sex, race/ethnicity, and regardless of a history of chronic kidney disease or obesity.

The team highlighted the clinical implications of this discovery. They emphasized that these findings could significantly influence clinical decision-making for diabetes patients who are at risk of developing kidney stones.

The study’s contribution is vital in the context of managing type 2 diabetes, a condition intricately linked with an increased risk of kidney stones.

The potential of SGLT2 inhibitors to mitigate this risk adds a new dimension to the treatment and management of diabetes, offering a dual benefit of managing blood sugar levels while also protecting against the development of kidney stones.

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The research findings can be found in JAMA Internal Medicine.

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