This drug can benefit people with heart failure and diabetes

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A significant study named the DAPPER study, involving 294 patients from 18 facilities in Japan, reveals new insights about the medication dapagliflozin in treating patients with chronic heart failure and type 2 diabetes.

The study was a multicenter trial, meaning it was conducted across various centers, with an open-label and controlled setup.

This design allowed researchers to observe the effects of dapagliflozin over two years, comparing it with standard treatments.

Although the usual recommended dose for heart failure is 10 mg, the study explored the effects of both 5 mg and 10 mg doses of dapagliflozin.

Primary Findings: Kidney Health

The primary focus of the study was to see if dapagliflozin could reduce urinary albumin excretion. This is a key marker indicating kidney damage, especially important in patients with diabetes and heart failure.

By the end of the study, 87.7% of the participants in the dapagliflozin group were taking the 5 mg dose. Interestingly, the study found that dapagliflozin did not significantly impact urinary albumin levels.

Secondary Findings: Cardiovascular Health

Despite the primary findings, the study revealed a significant secondary outcome. Patients in the dapagliflozin group showed a reduced incidence of cardiovascular events.

This included factors like cardiovascular death, hospitalizations due to heart issues, and the need for additional heart failure medication.

This reduction in cardiovascular events was observed in comparison to the group receiving standard treatments.

Implications for Treatment

This study is the first to report that a 5 mg dose of dapagliflozin can effectively reduce cardiovascular events in patients suffering from chronic heart failure and type 2 diabetes.

These findings are particularly promising as they offer new perspectives on treating these patients.

The results are expected to significantly influence clinical practices, providing a new avenue for managing heart health in patients with type 2 diabetes and chronic heart failure.


The DAPPER study sheds light on the potential benefits of dapagliflozin, especially at a 5 mg dosage, in reducing cardiovascular risks in diabetes patients with heart issues.

While it may not significantly impact kidney health markers like urinary albumin excretion, its role in enhancing cardiovascular health marks a significant step forward in diabetes and heart failure treatment.

This research paves the way for more tailored and effective treatment strategies for these patients.

If you care about heart health, please read studies about the best time to take vitamins to prevent heart disease, and scientists find how COVID-19 damages the heart.

For more information about diabetes, please see recent studies that low calorie diets may help reverse diabetes, and 5 vitamins that may prevent complication in diabetes.

The research findings can be found in eClinicalMedicine.

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