Study shows smaller doses and different injection method effective for mpox vaccine

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A recent study conducted by researchers at NYU Grossman School of Medicine highlights the effectiveness of delivering the mpox vaccine, known as JYNNEOS, in smaller doses and via intradermal injection between layers of the skin, compared to the standard subcutaneous injection under the skin.

The study demonstrates that this modified vaccination approach generates a detectable immune response against the mpox virus, regardless of whether individuals are living with or without HIV.

The research, which was published in the New England Journal of Medicine, involved middle school students from 116 schools in Stockholm County.

Students provided information about their sleep habits, including bedtime, wake times, sleep duration on school days and weekends, and their sleep preference or chronotype. They also reported on their perceived sleep quality, depressive symptoms, and thoughts of suicide.

The findings revealed that approximately half of the students slept fewer hours than the recommended 8-10 hours on school days. Many students identified themselves as “night owls,” a chronotype misaligned with the early start times of school.

Importantly, the study showed that students experiencing depressive symptoms or suicidal thoughts tended to sleep fewer hours on average than their peers without such symptoms.

Theresa Lemke, the corresponding author at NASP, emphasized the key discovery: “The main finding from this study is that adolescents with short sleep duration on school days and poor sleep quality are at higher risk of having depression and suicidal thoughts.

Given that nearly half of the adolescents in this study slept less than 8 hours on weekdays, this study highlights the need for interventions that aim at promoting sleep in adolescents.”

Promoting healthy sleep patterns among young people can significantly impact their overall well-being and development. The study suggests that adapting school hours to better align with adolescents’ natural sleep patterns could be a beneficial intervention.

Currently, early school start times may exacerbate the sleep deficit among young students, further underscoring the importance of reevaluating school schedules to prioritize their mental health.

In summary, the study underscores the critical importance of adequate sleep for middle school students’ mental health and suggests the need for interventions to promote healthy sleep habits among this population.

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The research findings can be found in New England Journal of Medicine.

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