A retrospective observational study has revealed that kidney dysfunction, particularly chronic kidney disease (CKD), poses a significant risk of mortality among stroke patients treated with thrombolysis.
This study underscores the critical role of kidney function in determining patient outcomes following thrombolysis for acute ischemic stroke.
Chronic kidney disease has long been recognized as a detrimental factor for cardiovascular health, contributing to the development of atherosclerosis and increasing mortality risk among patients with cardiovascular diseases.
However, its specific impact on thrombolysed stroke patients compared to other risk factors remained unclear.
Researchers conducted a retrospective observational study using electronic medical data from a cohort of 296 acute ischemic stroke patients who received thrombolysis between 2016 and 2020.
The study aimed to assess the significance of CKD relative to other cardiovascular risk factors and its effect on patient outcomes.
The evaluation included various factors such as age, sex, body mass index, obesity, hypertension, diabetes, high blood cholesterol, smoking, alcohol consumption, and a history of heart disease.
Neurological scores, including ASPECTS, Barthel index, mRS, and NIHSS, were employed to determine the relevance of each risk factor.
Kidney dysfunction was assessed using the estimated glomerular filtration rate (eGFR), a standard measure of kidney function.
Patients with an eGFR below 45-60 mL/min exhibited kidney dysfunction, which was closely associated with in-hospital mortality across all neurological scores. Remarkably, kidney dysfunction surpassed factors like age and blood creatinine levels in its impact on patient outcomes.
The study’s findings emphasize the need to incorporate kidney status into thrombolysis treatment guidelines for stroke patients.
Additionally, personalized treatment strategies tailored to patients with kidney dysfunction should be explored to enhance the safety and effectiveness of thrombolysis medication.
This study is the first to highlight the significance of CKD as a risk factor among stroke patients. The implications of this research are substantial and hold the potential to improve current stroke management protocols.
Future research endeavors, including prospective multi-center studies with diverse patient populations, will strengthen these findings and contribute to shaping future guidelines for stroke management.
In conclusion, identifying kidney dysfunction as a pivotal risk factor in thrombolysed stroke patients offers valuable insights into enhancing patient care and outcomes in this critical medical context.
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The research findings can be found in Medicine.
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