Steatotic liver disease (SLD) is a condition characterized by the accumulation of fat in the liver.
Researchers aimed to investigate the relationship between alcohol consumption and mortality risk in individuals with SLD, particularly those at low risk for advanced fibrosis.
The study analyzed data from the U.S. National Health and Nutrition Examination Survey III (1988 to 1994) database, tracking individuals through December 31, 2019.
Among the 2,834 individuals with SLD, 20.8% were at intermediate or high risk of advanced fibrosis. This group had a higher prevalence of metabolic disorders, and men were more predominant.
Key Findings:
Individuals at intermediate or high risk of advanced fibrosis had a higher mortality rate of 4,342 per 100,000 persons during 66,299 person-years of follow-up, compared to 1,099 per 100,000 persons in the low-risk group.
A nonlinear association between alcohol consumption and mortality was observed in the low-risk group. Mortality risk exceeded an adjusted hazard ratio of 1.00 at a daily alcohol intake of 7.4 grams.
In the intermediate- or high-risk groups, a linear association was identified between daily alcohol consumption and an increased risk of mortality.
This study suggests a nonlinear association between alcohol consumption and mortality risk in individuals with steatotic liver disease who are at low risk for advanced fibrosis.
Mortality risk increased significantly at or above a daily alcohol intake of 7.4 grams. For individuals with SLD, especially those at low risk, regular health monitoring and lifestyle management are recommended.
These findings align with previous research highlighting the risk of fibrosis progression in moderate drinkers.
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The research findings can be found in JAMA Network Open.
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