New research has raised concerns about the long-term use of topical corticosteroids, commonly prescribed for inflammatory skin conditions.
The study, published in the Journal of the European Academy of Dermatology and Venereology, used data from the Taiwan National Health Insurance Research Database to examine the relationship between these medications and the risk of osteoporosis and major osteoporotic fractures (MOF).
The investigation involved a large sample size, including 129,682 cases of osteoporosis and 34,999 cases of MOF.
These cases were matched with 518,728 and 139,996 controls, respectively, based on sex and age. The controls were individuals without osteoporosis or MOF.
A key finding of the study was a clear dose-response relationship between the long-term use of topical corticosteroids and an increased risk of developing osteoporosis and MOF.
In comparison to individuals who did not use these medications, those who used low, medium, and high cumulative doses of topical corticosteroids had 1.22, 1.26, and 1.34 times higher odds, respectively, of developing osteoporosis over five years.
Similarly, these dose levels were associated with 1.12, 1.19, and 1.29 times higher chances, respectively, of experiencing MOF.
One notable aspect of the study was that women faced higher risks of osteoporosis and MOF compared to men.
Additionally, the research revealed that individuals younger than 50 had a higher risk of developing osteoporosis compared to older age groups.
Dr. Chia-Yu Chu, MD, Ph.D., the corresponding author from National Taiwan University Hospital and National Taiwan University College of Medicine, emphasized the importance of cautious use of topical corticosteroids.
He highlighted the need for clinicians to be aware of these potential side effects.
This research underscores the necessity of weighing the benefits and risks when prescribing topical corticosteroids, especially for long-term use.
It calls for careful consideration and monitoring, particularly for patients who may be at higher risk of bone-related issues.
The findings point to a need for further research and awareness among healthcare providers and patients about the potential long-term impacts of commonly used dermatological treatments.
As the medical community continues to understand and manage the risks associated with these medications, this study serves as a reminder of the importance of personalized and cautious healthcare practices.
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The research findings can be found in the Journal of the European Academy of Dermatology and Venereology.
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