Scientists find an important treatment for vascular dementia

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A recent study led by researchers from St George’s University and other institutions has revealed promising results in using the drug tadalafil for treating vascular dementia, offering hope in a field where treatment options are limited.

Currently, 55 million people worldwide are affected by dementia, a number expected to rise to 139 million by 2050.

This study concentrates on vascular dementia, where reduced blood flow to the brain is a key factor.

Tadalafil’s Role in Dementia Treatment

Tadalafil, commonly used for pulmonary hypertension, could potentially be repurposed for dementia treatment.

The drug is thought to increase blood flow in the brain, thereby enhancing the health of brain cells.

Selected for its longer half-life and ability to penetrate the brain, tadalafil stands out compared to similar drugs.

Study Findings and Implications

Increased Blood Flow in Older Participants: The study noted a trend toward improved blood flow in the brain’s white matter, crucial in vascular dementia, particularly in participants over 70 years of age.

Safety Profile: No serious adverse events were reported, indicating the drug’s safety for patients.

Future Research: Further investigations are suggested, especially focusing on older age groups and extending the duration of the study.


The study on tadalafil offers a new avenue for vascular dementia treatment, a domain where medical options are currently scarce.

Its potential to improve blood flow in the brain could be a significant step forward in managing this form of dementia, warranting further research and trials.

If you care about brain health, please read studies about how the Mediterranean diet could protect your brain health, and blueberry supplements may prevent cognitive decline.

For more information about brain health, please see recent studies about antioxidants that could help reduce dementia risk, and Coconut oil could help improve cognitive function in Alzheimer’s.

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