Promising drug may halt pancreatic cancer spread

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Pancreatic cancer is a formidable foe, with a high mortality rate, especially when it has metastasized or spread to other parts of the body.

While advancements have been made in treating various types of cancer, pancreatic cancer remains a challenge, with only around 3.2% of patients surviving five years after a metastatic diagnosis.

However, there’s hope on the horizon as researchers work tirelessly to develop new treatments that could potentially stop this aggressive cancer in its tracks.

Understanding Pancreatic Cancer

Before we delve into the promising drug, let’s briefly understand pancreatic cancer. The pancreas is a vital organ located behind the stomach, and it plays a crucial role in digestion and regulating blood sugar.

When cancer develops in the pancreas, it can disrupt these functions and rapidly spread to other parts of the body.

Metastatic Pancreatic Cancer

Metastatic pancreatic cancer is a particularly challenging form of the disease. Once cancer cells break away from the pancreas and travel to other organs or tissues, treatment becomes much more difficult.

Current survival rates for metastatic pancreatic cancer are disheartening, making the development of effective treatments a top priority in cancer research.

The New Drug

Dr. Vladimir Bogdanov, from the University of Cincinnati Cancer Center, is at the forefront of this fight against pancreatic cancer. He and his team have developed a novel drug designed to thwart the growth and spread of cancer cells.

This drug focuses on a specific molecule that tends to be overexpressed in cancer cells, driving their growth and spread.

The drug, created in Dr. Bogdanov’s lab, is a humanized antibody engineered to target and neutralize the troublesome molecule, with the goal of halting the progression of cancer.

Researchers conducted tests to assess the drug’s effectiveness when combined with standard chemotherapy treatments for pancreatic cancer using animal models.

The findings from these tests are encouraging. In the absence of treatment, cancer cells readily spread. Standard chemotherapy reduced the spread by about half.

However, when the new drug was administered alongside chemotherapy, it had an even more substantial suppressive effect, sometimes preventing cancer from spreading altogether.

Significance of the Findings

One of the most critical implications of this research is the drug’s potential to inhibit metastasis, which is the primary cause of death in pancreatic cancer cases.

Additionally, the drug appears to complement standard-of-care chemotherapy treatments, which is a significant development from a clinical perspective.

Moving forward, Dr. Bogdanov’s team plans to test the drug in combination with chemotherapy in various pancreatic cancer cell lines and patient-derived tissue samples.

The goal is to further validate its effectiveness and safety. Additionally, they are working on scaling up the drug’s production in preparation for early-stage clinical trials.

The journey to develop this drug has been long and demanding, but Dr. Bogdanov and his team have persevered since starting the prototype in 2009. Their success has been buoyed by the support of the Cancer Center’s research community, leadership, and shared resources.

The collaborative effort of researchers, funding agencies, and patient support has been instrumental in advancing this promising treatment.


Pancreatic cancer remains a formidable challenge in the world of oncology. However, the development of a drug that shows promise in halting its spread offers newfound hope for patients.

Dr. Bogdanov’s dedication and the collaborative efforts of the research community shine a light on the potential for more effective treatments, ultimately improving the outlook for individuals battling this aggressive form of cancer.

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