Early coronary heart disease linked to higher dementia risk

Credit: Unsplash+

Coronary heart disease (CHD) is a known risk factor for dementia, but new research suggests that the age at which CHD is diagnosed can significantly impact the risk of developing dementia later in life.

This study, published in the Journal of the American Heart Association, explores the relationship between early-onset CHD and the subsequent risk of dementia, Alzheimer’s disease, and vascular dementia.

The Link Between CHD and Dementia

Previous research has established a connection between CHD and dementia risk in older adults. However, this study is among the first to investigate the impact of the age at which CHD is diagnosed on dementia risk.

The researchers aimed to uncover whether early-onset CHD, particularly before the age of 45, posed a more significant threat.

The study involved an analysis of health data from the UK Biobank, a large biomedical database with records from around 500,000 adults in the United Kingdom.

The data, collected from 2006 to 2010, included information on participants’ health and demographics, as well as details about their CHD diagnoses and dementia outcomes.

Key Findings

The analysis of 432,667 participants revealed several important findings:

Increased Dementia Risk: Participants with CHD had a 36% higher risk of developing dementia, a 13% increased risk of Alzheimer’s disease, and a staggering 78% greater risk of vascular dementia compared to those without CHD.

Age Matters: Early-onset CHD, diagnosed before age 45, was associated with a 25% increased risk of dementia, a 29% increased risk of Alzheimer’s disease, and a 22% increased risk of vascular dementia. Notably, the risk of dementia rose with a younger age of CHD onset.

Linear Relationship: The study revealed a linear relationship between the age at which CHD was diagnosed and dementia risk. This underscores the significant impact of premature CHD on brain health.

Implications and Future Directions

These findings emphasize the critical need for healthcare professionals to recognize and address the increased dementia risk in individuals diagnosed with CHD, especially at a young age.

Early-onset CHD not only poses immediate health concerns but also has long-term consequences for cognitive function.

The study’s lead author, Dr. Fanfan Zheng, highlights the importance of modifying cardiovascular risk factors early in life to promote better brain health in the future.

While the study does not establish a cause-and-effect relationship, it underscores the need for proactive measures to reduce the risk of both CHD and subsequent dementia.


Coronary heart disease diagnosed at an early age, particularly before 45, is associated with a significantly higher risk of dementia, Alzheimer’s disease, and vascular dementia.

This study serves as a wake-up call for healthcare professionals to prioritize the brain health of patients with CHD, emphasizing the importance of timely intervention and risk factor management to mitigate these risks.

As the aging population grows, addressing these health concerns becomes increasingly critical for improving overall well-being.

If you care about dementia, please read studies about Vitamin D deficiency linked to Alzheimer’s, vascular dementia, and Oral cannabis extract may help reduce Alzheimer’s symptoms.

For more information about brain health, please see recent studies that herb rosemary could help fight COVID-19, and Alzheimer’s disease, and results showing this stuff in mouth may help prevent Alzheimer’s.

The research findings can be found in the Journal of the American Heart Association.

Copyright © 2023 Knowridge Science Report. All rights reserved.