This wearable patch could monitor estrogen in sweat wirelessly

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Estrogen, a hormone primarily associated with women’s health, plays a crucial role in various aspects of female fertility and overall well-being.

It has numerous responsibilities, like developing secondary sexual characteristics in women and overseeing the reproductive cycle.

Too much estrogen is linked to breast and ovarian cancers, while too little can lead to osteoporosis, heart disease, and depression.

For women, monitoring estrogen levels is essential, especially estradiol, the most powerful form of estrogen, typically requiring clinical visits and blood tests.

However, scientists from Caltech have designed a ground-breaking wearable sensor that can detect and monitor estradiol levels through sweat, potentially simplifying the way women can monitor these levels from the comfort of their homes and in real-time.

This exciting research was led by Wei Gao, an expert in medical engineering.

This invention is primarily aimed at women attempting to conceive a child, as precise monitoring of estradiol can help optimize the timing related to ovulation, ensuring a higher success rate in conception, either naturally or via in vitro fertilization.

This sensor is also beneficial for women undergoing hormone replacement therapy to closely monitor and adjust their estradiol levels.

The sweat sensor created by Gao’s team is flexible and is developed with intricate channels, microfluidics, to direct sweat into the sensor efficiently.

It uses inkjet-printed gold nanoparticles and titanium carbide films, enhancing the sensor’s surface area and sensitivity. The sensor is tailored to accurately detect estradiol, which is significantly less concentrated in sweat compared to blood.

To achieve this, the sensor utilizes aptamers, short single-stranded DNA known to act as artificial antibodies, specifically binding to a target molecule, in this case, estradiol.

The sensor detects estradiol by releasing a molecule when an aptamer binds to an estradiol molecule, generating an electrical signal corresponding to the estradiol level. This data is then wirelessly transmitted to a smartphone app, allowing users to monitor their estradiol levels seamlessly.

The sensor is designed to admit a fixed amount of sweat, preventing additional sweat from interfering with the estradiol analysis. It also compensates for variances in sweat composition by monitoring sweat pH, salt levels, and skin temperature, ensuring accurate real-time results.

Tests in the lab have demonstrated that the sensor can reliably track estradiol levels in sweat throughout the reproductive cycle, presenting a future where women can discreetly monitor their hormone levels using such devices.

Gao is ambitious about refining this technology to include the ability to monitor other female hormones like luteinizing hormone or progesterone, which play a vital role in ovulation.

His vision includes miniaturizing these sensors to fit inside a small, inconspicuous wearable device, like a ring.

This wearable sensor marks a pivotal moment in women’s healthcare, allowing women more autonomy and convenience in monitoring their health.

It represents the convergence of medicine and technology, leading to innovative solutions that can significantly impact women’s lives, especially those planning pregnancies or undergoing hormone therapies.

The ease of use and real-time data availability make it a promising solution for many women worldwide.

This innovation not only stands as a testament to the advancements in medical technology but also opens up possibilities for further research and development in the field of wearable healthcare devices.

It’s a step forward in making healthcare more accessible, user-friendly, and efficient, offering hope for more such innovations in the future, catering to various healthcare needs and conditions.

The research, titled “A wearable aptamer nanobiosensor for non-invasive female hormone monitoring,” was published in Nature Nanotechnology.

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Source: California Institute of Technology.