Scientists find an important cause of chronic inflammation

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Inflammation is a crucial component of the body’s healing process.

However, when inflammation becomes chronic, it can contribute to the development of various complex diseases, including type 2 diabetes, heart disease, and autoimmune disorders.

Recent genetic research conducted at the University of South Australia has established a direct connection between low levels of vitamin D and heightened inflammation.

This discovery provides a valuable biomarker for identifying individuals at a higher risk of chronic illnesses with an inflammatory component.

The Study

The study focused on genetic data from a staggering 294,970 participants enrolled in the UK Biobank.

Using a technique called Mendelian randomization, the researchers investigated the association between vitamin D levels and C-reactive protein (CRP) levels—an established indicator of inflammation.

Dr. Ang Zhou, the lead researcher at the University of South Australia, explained that the study’s findings imply that increasing vitamin D levels in individuals with deficiencies could potentially reduce chronic inflammation.

The Role of Inflammation

Inflammation serves as the body’s natural defense mechanism to protect tissues in the event of injury or infection.

The liver produces high levels of C-reactive protein (CRP) in response to inflammation. Thus, when the body experiences chronic inflammation, it tends to exhibit elevated CRP levels.

Dr. Zhou elaborated, stating, “This study examined vitamin D and C-reactive proteins and found a one-way relationship between low levels of vitamin D and high levels of C-reactive protein, expressed as inflammation.”

Potential Health Benefits

The research suggests that increasing vitamin D levels in individuals with deficiencies may help reduce chronic inflammation, potentially preventing the development of related diseases.

Adequate vitamin D concentrations could also mitigate complications associated with obesity and reduce the risk or severity of chronic illnesses characterized by inflammation, such as cardiovascular diseases (CVDs), diabetes, and autoimmune conditions.

Professor Elina Hyppönen, senior investigator and Director of UniSA’s Australian Centre for Precision Health, emphasized the significance of these findings.

She noted that while some individuals with very low vitamin D levels experience clear health benefits from increasing their vitamin D concentrations, others may show limited or no improvement.


The study’s results underscore the importance of avoiding clinical vitamin D deficiency and offer further evidence of the far-reaching effects of hormonal vitamin D.

By understanding the link between low vitamin D levels and chronic inflammation, healthcare providers can better identify individuals at risk and implement strategies to optimize their vitamin D levels, potentially reducing the risk and severity of chronic inflammatory diseases.

If you care about liver health, please read studies about simple habit that could give you a healthy liver, and common diabetes drug that may reverse liver inflammation.

For more information about health, please see recent studies about simple blood test that could detect your risk of fatty liver disease, and results showing this green diet may strongly lower non-alcoholic fatty liver disease.

The research findings can be found in the International Journal of Epidemiology.

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