How a compound in coffee may boost your cognitive function

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The quest for natural solutions to combat age-related cognitive decline is gaining momentum, with the goal of promoting healthier aging.

Trigonelline (TG), a compound found in everyday beverages and foods like coffee, fenugreek seeds, and radishes, has recently been under the spotlight for its potential cognitive-enhancing properties.

Exploring Trigonelline’s Potential

In a detailed study published in GeroScience, a team of researchers from the University of Tsukuba delved deep into understanding how TG affects memory and learning, specifically spatial learning—the ability to acquire and use information about one’s surroundings.

They used a specific type of mouse, known as the senescence-accelerated mouse prone 8 (SAMP8), to explore TG’s impact.

Improvements in Learning and Memory

The mice were given TG orally for a period of 30 days.

Their performance in a Morris water maze test showed remarkable improvement in spatial learning and memory compared to those who didn’t receive TG, suggesting that TG could positively impact cognitive functions related to learning and memory retention.

Discovering the Underlying Mechanisms

To comprehend how TG imparts these benefits, the team examined the gene expression in the hippocampus, a brain region pivotal for memory and learning.

They discovered that TG altered several signaling pathways associated with brain development, energy production, inflammation, cellular cleaning processes, and neurotransmitter release.

TG appeared to suppress inflammation in the brain by moderating the activation of specific signaling and transcription factors.

The team also observed that TG significantly reduced the levels of inflammatory molecules and increased the levels of essential neurotransmitters, like dopamine and serotonin, in the brain.

These neurotransmitters play a crucial role in regulating mood, sleep, and learning.

A Natural Approach to Cognitive Enhancement

These findings present a promising prospect for TG in alleviating age-associated memory and learning impairments.

This research sheds light on how daily consumables like coffee may harbor compounds capable of enhancing cognitive functions, potentially aiding in the battle against cognitive decline as we age.


This enlightening study uncovers the potential cognitive benefits of Trigonelline, a natural compound found in coffee, revealing its positive impact on learning and memory.

By modulating various brain functions and reducing inflammation, TG stands out as a promising candidate for promoting brain health and combatting age-related cognitive decline.

It opens the door to further exploration into how everyday natural compounds can be harnessed to support cognitive health and healthy aging.

If you care about Alzheimer’s, please read studies about Vitamin D deficiency linked to Alzheimer’s, vascular dementia, and Oral cannabis extract may help reduce Alzheimer’s symptoms.

For more information about brain health, please see recent studies about Vitamin B9 deficiency linked to higher dementia risk, and results showing flavonoid-rich foods could improve survival in Parkinson’s disease.

The research findings can be found in GeroScience.

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