University of Georgia (UGA) researchers David Chu and Uma Singh have developed and patented a molecule that could be a potential treatment for varicella zoster virus, responsible for chickenpox and shingles.
The varicella zoster virus is responsible for causing both chickenpox and shingles.
If a person had chickenpox during childhood, the virus remains dormant in their body and can reactivate later in life, leading to shingles.
A study in the Journal of Medicinal Chemistry reveals that a molecule developed by the UGA team can effectively treat shingles lesions.
Additionally, it indicates potential effectiveness against the viruses that cause oral and genital herpes.
Existing treatments for herpes and shingles viruses are either not very effective or can cause severe side effects. Current medications are becoming less effective as many viruses become drug-resistant.
The New Drug
It is called POM-L-BHDU. The molecule is safe for treating varicella zoster virus even in cancer patients.
It can be taken orally, intravenously, or applied topically. This versatility suggests its potential use in cream-based medications for herpes outbreaks and shingles.
POM-L-BHDU has shown a higher potency against the virus than current treatments.
Researchers found that applying the molecule topically can prevent the spread of the virus to other body parts.
Such localized application also reduces the quantity of the drug absorbed into the bloodstream, minimizing side effects.
The molecule can act against varicella zoster virus as well as herpes simplex 1 and 2 viruses.
Over-the-counter Hopes
The researchers envision that the topical formula can be sold without a prescription, allowing patients to access treatment conveniently at home.
The molecule has already shown success in vitro and in vivo mouse models. Topical studies on human skin have indicated its effectiveness against herpes simplex 1 and the varicella zoster viruses.
The next goal is to move the molecule into phase 1 clinical trials. The UGA Research Foundation has licensed this molecule to Anterogen Co.
The molecule developed by the UGA team holds the promise to revolutionize the treatment of herpes and shingles viruses, potentially benefiting a significant number of patients worldwide.
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The study was published in the Journal of Medicinal Chemistry.
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