Social isolation may be a big cause of depression in adults

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Depression is a mental health disorder that is pervasive worldwide, affecting millions of people and severely impacting an individual’s quality of life.

A recent study conducted by a team of scientists from Colorado State University has shed light on the factors that contribute to depression, with social isolation being identified as a primary risk factor in middle-aged and older adults.


The research team employed a machine learning approach, a subset of artificial intelligence, to scrutinize data from a large, population-representative sample of middle-aged and older adults residing in Europe.

The machine learning model was trained on 56 variables, including demographic factors, health status, and socioeconomic indicators, to identify patterns and associations that could predict the risk of depression.


Among the numerous variables scrutinized, social isolation emerged as the leading risk factor for depression in both men and women.

This finding signifies the detrimental effect of loneliness and lack of social interaction on the mental health of individuals, especially as they age.

Following social isolation, general poor health and mobility difficulties were found to be significant contributors to depression.

The research team further analyzed 30 variables related to participants’ social networks and family configurations.

These factors included the frequency of contact with friends and family, the number of friends, and interpersonal transactions related to physical care and financial support.

In men, difficulty in instrumental activities of daily life, such as managing finances, taking medications, and making telephone calls, was identified as a fourth key risk factor.

For women, a family burden emerged as a fourth significant risk factor, with women who strongly agreed with the statement, “family responsibilities get in the way of my being able to do the things I want to do,” being at an elevated risk for depression.

However, the study found that these gender-specific factors accounted for only a small proportion of differences in depression risk, indicating that depression is influenced by a complex interplay of various factors.


The findings of this study underscore the importance of social support and connectedness in reducing the risk of depression, particularly in middle-aged and older adults.

The researchers, led by Stephen Aichele, believe that understanding various risk and protective factors for depression can guide interventions to prevent and manage depression more effectively.

Given the strong association between self-reported social isolation and depression, the research team suggests that healthcare providers pay special attention to different dimensions of social and relational support when working with patients at risk for depression.

The researchers also advocate for more studies that delve into the multifaceted nature of social and relational support, to better comprehend its relationship with mental health.


Published in The Lancet Regional Health—Europe, this study serves as a reminder of the crucial role that social connections play in our mental well-being.

As we age, these connections can become even more vital, highlighting the need for initiatives that combat social isolation and foster social engagement among middle-aged and older adults.

Ultimately, the researchers hope that their findings will help enhance prevention and intervention strategies for depression, paving the way for improved mental health outcomes for millions of people worldwide.

If you care about depression, please read studies that vegetarian diet may increase your depression risk, and Vitamin D could help reduce depression symptoms.

For more information about health, please see recent studies that ultra-processed foods may make you feel depressed, and these antioxidants could help reduce the risk of dementia.

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