Scientists from the University of Auckland have carried out an intriguing study on the effects of alpelisib, a drug typically used to treat cancer.
Their research sought to examine whether this drug could also influence the aging process.
The Experiment: Alpelisib and Aging
In the experiment, one group of healthy mice received a regular diet, while another group was fed the same diet laced with alpelisib.
The drug treatment started when the mice were middle-aged (around one year old) and lasted for an extended period.
The scientists found that mice given the alpelisib-enhanced diet lived about 10% longer, averaging about three years.
The drug-treated mice also showed improved health indicators in old age, such as enhanced coordination and strength.
Caution: Potential Drawbacks and Side Effects
Despite the exciting results, the researchers urge caution when considering the drug’s potential application to humans.
The treated mice, despite living longer, exhibited some negative aging markers, including lower bone mass. Additionally, alpelisib carries side effects that could prove harmful if taken long-term.
The Bigger Picture: Alpelisib, PI 3-Kinase, and Aging
Alpelisib’s significance extends beyond its current use in cancer treatment. It targets an enzyme called PI 3-kinase, which scientists believe plays a role in both cancer and aging.
For over two decades, researchers have been developing drugs targeting PI 3-kinase, mainly focusing on cancer treatments.
This study suggests that these drugs might have broader applications, such as extending lifespan and treating metabolic health conditions.
More research is required to fully understand alpelisib’s effects on aging and to pinpoint any potential risks associated with its use.
Nonetheless, this study represents an important stride in the timeless quest for extending human life and improving health.
Other Recent Research on Aging and Longevity
The Auckland study is not alone in its pursuit. Other recent research suggests that animal protein might be more beneficial than plant protein for aging muscles.
Another study proposes that olive oil could contribute to a longer life, while vitamin D has been associated with a lower risk of autoimmune diseases.
These findings underscore the importance of long-term research into aging and disease mechanisms.
They also highlight the need to explore new treatments and therapies that could improve human health and extend lifespan.
The pursuit of longevity continues, and each study brings us a step closer to understanding the complex process of aging.
If you care about heart health, please read studies about the best blood sugar levels to prevent strokes and heart attacks, and Vitamin K may lower your heart disease risk by a third.
For more information about heart health, please see recent studies about why obesity increases heart damage in COVID-19, and results showing this drug combo can halve your risk of heart attack and stroke.
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