An estimated one in six older adults in the United States who take multiple prescription drugs risk major drug-drug interactions and other adverse drug effects.
This can worsen their medical conditions, increase the likelihood of cognitive impairment and falls, and lead to hospitalization or death.
Deprescribing is a systematic effort to identify, reduce the dose or stop unnecessary or potentially inappropriate medications in a manner that is safe and effective.
In a study from Vanderbilt University, scientists developed Sheds-MEDS, a hospital-based, pharmacist- or nurse practitioner-led, and patient-centered deprescribing protocol can help reduce dangerous drug interactions.
They found that implementing the Shed-MEDS protocol in the hospital prior to discharge to a post-acute care facility, such as a nursing/rehabilitation center, significantly reduced the number of medications patients received.
While the rates of adverse drug events were similar between patients randomly selected to receive the deprescribing intervention and a control group that did not, the reduced medication burden persisted for at least 90 days.
Moreover, the intervention additionally reduced exposure to potentially inappropriate medications.
This study demonstrates that the hospital may be a safe and effective healthcare setting to help address the epidemic of polypharmacy often seen in older hospitalized adults.
Furthermore, post-acute care settings, such as skilled nursing facilities, may be valuable partners to continuing safe deprescribing practice.
The team says further research is necessary to determine the impact of deprescribing on long-term clinical outcomes.
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The study was conducted by Eduard Vasilevskis et al and published in the journal JAMA Internal Medicine.
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