This COVID-19 vaccine may prevent brain damage caused by infection

Credit: Robina Weermeijer / Unsplash

The pathology of the respiratory system is the main impact of COVID-19.

But many people also have neurological symptoms, such as loss of smell (anosmia), headaches, malaise, cognitive loss, epilepsy, ataxia and encephalopathy, among others.

In a study from the University of Seville in Spain, scientists found a vaccine against COVID-19 can protect against infection and brain damage caused by the virus.

They demonstrated the ability of the COVID virus to infect different regions of the brain and to cause brain damage, and how the CNB-CSIC vaccine fully protects against infection of the brain.

Researchers have studied viral infection in different brain regions, noting that viral replication occurs mainly in neurons, producing neuronal loss, glial activation, and vascular damage.

Once the infection in the brain by COVID-19 was examined, the researchers tested the efficacy of the vaccine against COVID-19 developed at the CNB-CSIC.

They immunized mice with one or two doses of the MVA-CoV2-S vaccine, based on the modified vaccinia virus Ankara (MVA) expressing the spike (S) protein of SARS-CoV-2, and analyzed the capability to protect against infection and damage to the brain.

The results showed that even the administration of a single dose of the MVA-CoV2-S vaccine completely prevents COVID infection in all brain regions and it prevents associated brain damage, even after reinfection with the virus.

This shows the great efficacy and immunogenic power of the vaccine that induces sterilizing immunity in the brain.

These results reinforce previous data on the immunogenicity and efficacy of the MVA-CoV2-S vaccine in various animal models.

The team says the results have important long-term implications for understanding the infection caused by SARS-CoV-2.

If you care about COVID, please read studies about Vitamin D deficiency linked to severe COVID-19, and scientists find new drug to treat both COVID-19 and cancer.

For more information about health, please see recent studies about evidence on rare blood clots after COVID-19 vaccination, and results showing how Mediterranean diet could protect your brain health.

The study was conducted by Dr. Javier Villadiego et al and published in Nature Neuroscience.

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