A study from the University of Waterloo scientists found that people who are taking a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure should be cautious about also taking ibuprofen.
Diuretics and RSA inhibitors are commonly prescribed together for people with hypertension and are available under various pharmaceutical brand names.
Painkillers such as ibuprofen are available over-the-counter in most pharmacies and stores in popular brands.
In the study, the team used computer-simulated drug trials to model the interactions of the three drugs and the impact on the kidney.
They found that in people with certain medical profiles, the combination can cause acute kidney injury, which in some cases can be permanent.
The team says it’s not that everyone who happens to take this combination of drugs is going to have problems. But the study shows it can be a problem that people should exercise caution.
The research can also speak directly to the many people who are taking drugs for high blood pressure and may reach for a painkiller with ibuprofen without giving it much thought.
Diuretics are a family of drugs that make the body hold less water. Being dehydrated is a major factor in acute kidney injury, and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy.
If people happen to be on these high blood pressure drugs and need a painkiller, consider acetaminophen instead.
The research was conducted by Anita Layton et al.
If you care about kidney health, please read studies that Mediterranean diet could help protect kidney health, and DASH diet for high blood pressure can protect kidney health.
For more information about kidney health, please see recent studies about drug that prevents kidney failure in diabetes, and results showing cruciferous vegetables may reduce kidney damage in diabetes.
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