Regular physical activity could make COVID-19 vaccine more effective

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There’s convincing evidence that regular physical activity helps ward off the consequences of serious COVID-19 infection, reducing the risk of hospital admission, intensive care, assisted ventilation, or death.

Similarly, vaccination also minimizes these risks.

In a study from the University of the Witwatersrand and elsewhere, scientists found that regular physical activity may boost the effectiveness of the COVID-19 jab, with the level of protection afforded against serious infection rising in tandem with the amount of physical activity done.

Previously published research on the additive effects of physical activity on vaccination against various infections suggests that it enhances the body’s antibody response.

But it’s not known if this might also apply to SARS-CoV-2, the virus responsible for COVID-19 infection.

In the study, the researchers drew on anonymized medical records and wearable activity tracker data for healthcare workers belonging to a medical insurance scheme as well as a health promotion and behavioral change program.

Participants were mapped to physical activity categories using their average monthly levels in the 2 years preceding the start of the study: under 60 minutes of a week (low); at least 60-149 minutes (medium); and 150 minutes + (high).

COVID-19 swab test results were analyzed for 53,771 participants with low levels of physical activity, 62,721 with medium levels, and 79,952 with high levels.

Complete health, COVID-19 vaccination (mid-February to the end of October 2021; Janssen Ad26.COV2.S COVID-19), and physical activity data were obtained for 196,444 adults who tested negative for SARS-CoV-2.

The team found vaccine effectiveness against COVID-19 among fully vaccinated people in the low physical activity category was 60%.

In other words, the risk of hospital admission was reduced by 60% in this group.

Comparable risk reductions for those in the medium and high physical activity groups were, respectively, 72% and 86%.

Those who were fully vaccinated and who clocked up high weekly levels of physical activity were nearly 3 times less likely to be admitted to the hospital than those who were vaccinated but in the low physical activity category.

Similarly, those in the medium physical activity category were nearly 1.5 times less likely to be admitted to the hospital with COVID-19 infection.

The findings suggest a possible dose response where high levels of physical activity were associated with higher vaccine effectiveness.

This substantiates the WHO recommendations for regular physical activity—namely, that 150-300 mins of moderate-intensity physical activity per week have meaningful health benefits in preventing severe disease, in this context against a communicable viral infection.

If you care about COVID, please read studies about the cause of post-COVID syndromes, and how vitamin B may help fight COVID-19.

For more information about COVID, please see recent studies about new evidence on rare blood clots after COVID-19 vaccination, and results showing an inexpensive, readily available drug that may treat COVID-19.

The study was conducted by Shirley Collie et al and published in the British Journal of Sports Medicine.

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