Scientists from Children’s Hospital of Philadelphia found multiple causal genes that drive the risk of type 2 diabetes.
They used advanced three-dimensional mapping techniques at a microscopic level to identify genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.
The resulting datasets will serve as a key resource for researchers all over the world to delve deeper into the genetic origins of type 2 diabetes.
Type 2 diabetes cases are on the rise and being diagnosed in patients earlier in life than what has been historically observed.
However, while many cases can be attributed to a rise in obesity and a sedentary lifestyle, increasing evidence suggests a strong role that genetic risk factors play in this relatively common disease.
In the study, the team created three-dimensional profiles of purified acinar, alpha, and beta cells in the human pancreas, using a variety of techniques that examined each of them at the single-cell level.
They identified a series of causal variants and target gene pairs at 194 different Type 2 diabetes signals.
Additionally, the study revealed that alpha and acinar cells likely play a greater role in the development of type 2 diabetes than previously thought.
The tram says prior studies appear to support many of the findings we made in the process of this work, and with additional validation and imaging tools, more aggressive drivers of type 2 diabetes pathogenesis at a genetic level can be isolated.
They believe the findings of this study will serve as a crucial resource for the diabetes research community.
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The research was published in the journal Cell Metabolism and conducted by Andrew D. Wells et al.
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