In a study from Johns Hopkins University, scientists found that body posture affects how oral drugs are absorbed by the stomach.
A common, economic, and easy method of administering drugs is oral, by swallowing a pill or capsule.
But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient.
This is because the bioavailability of the drug in the gut tract depends on the medication’s ingredients and the stomach’s dynamic physiological environment.
In the study, the team used a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach—a “StomachSim”—to examine how body posture affects drug bioavailability.
They found when the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves. The properties of the pill and the stomach contents also play a major role.
The new computer models can generate relevant data on drug dissolution that can provide useful and unique insights into the complex physiological processes behind the oral administration of pills.
The modeling appears to be the first of its kind to couple gastric biomechanics with pill movement and drug dissolution to quantify an active pharmaceutical ingredient passing through the pylorus into the duodenum.
The model enabled the researchers to calculate and compare the emptying rate and the release of a dissolved active pharmaceutical ingredient into the duodenum for a variety of physiological situations.
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The was conducted by Rajat Mittal et al and published in Physics of Fluids.
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