Scientists develop a new treatment for common knee injury

Credit: CC0 Public Domain.

Each year in the U.S., more than 500,000 people sustain tears in their meniscus, a piece of cartilage in the knee that cushions and stabilizes the joint.

The tears often require invasive surgeries that frequently do not achieve the desired outcome.

Scientists from the University of Cincinnati are developing therapies that use a regenerative approach to meniscal tears that could benefit soldiers, athletes, and weekend warriors by making those surgeries more reliable.

One such therapy is the drug AM3101, which has recently cleared the Investigational New Drug (IND) application by the Food and Drug Administration.

Physicians have long recognized that while a surgical repair is often the best approach for patients with meniscal tears, surgery alone still fails to achieve effective healing in nearly one in four cases.

Given that meniscal tears are one of the top diagnoses evaluated by military health care professionals, it is critical to advance this promising therapy into the operating room and eventually the military community.

AM3101 is an injectable drug being developed as a therapy to reduce the frequency of complications and morbidities associated with failed meniscal repair surgery.

Meniscal tears, particularly in the portion of the tissue lacking sufficient blood supply, are often irreparable and require the removal of the diseased tissue.

AM3101 could be added to a repair to allow for successful healing in previous irreparable tear patterns.

AM3101 is developed by Amplicore, a startup biopharmaceutical company. Research has shown that it provides pain relief and promotes the regeneration of damaged tissue.

If proven to be successful, this treatment could have a positive impact on a wide range of people.

This treatment has the possibility to help athletes keep doing the sports they love and keep the ‘average Joe’ from having knee pain. Furthermore, if successful it will keep our troops healthy.

The team says this will hopefully help unlock a “black box” of reliable and restorative healing for a problem that affects millions of Americans.

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The research was conducted by Brian Grawe et al.

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