Despite significant and stunning advances in vaccine technology, the COVID-19 global pandemic is not over.
A key challenge in limiting the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is identifying infected individuals.
Scientists from Japan found have developed a new antibody-based method for the rapid and reliable detection of SARS-CoV-2 that does not require a blood sample.
The research was conducted by Leilei Bao et al.
The ineffective identification of SARS-CoV-2-infected individuals has severely limited the global response to the COVID-19 pandemic, and the high rate of asymptomatic infections (16%–38%) has exacerbated this situation.
The predominant detection method to date collects samples by swabbing the nose and throat.
However, the application of this method is limited by its long detection time (4–6 hours), high cost, and requirement for specialized equipment and medical personnel, particularly in resource-limited countries.
An alternative and complementary method for the confirmation of COVID-19 infection involves the detection of SARS-CoV-2-specific antibodies.
Testing strips based on gold nanoparticles are currently in widespread use for point-of-care testing in many countries.
They produce sensitive and reliable results within 10–20 minutes, but they require blood samples collected via a finger prick using a lancing device.
This is painful and increases the risk of infection or cross-contamination, and the used kit components present a potential biohazard risk.
In the study, the team explored the idea of sampling and testing the interstitial fluid (ISF), which is located in the epidermis and dermis layers of human skin.
Although the antibody levels in the ISF are approximately 15%–25% of those in blood, it was still feasible that anti-SARS-CoV-2 IgM/IgG antibodies could be detected and that ISF could act as a direct substitute for blood sampling.
After demonstrating that ISF could be suitable for antibody detection, the researchers developed an innovative approach to both sample and test the ISF.
They created a compact patch capable of on-site detection of the antibodies within 3 minutes.
This novel detection device has great potential that is safe and acceptable to patients for the rapid screening of COVID-19 and many other infectious diseases.
It holds promise for use in many countries regardless of their wealth, which is a key aim for the global management of infectious diseases.
If you care about COVID, please read studies about the key to curing COVID-19, and COVID-19 vaccines are only 66% effective against Delta variant.
For more information about COVID, please see recent studies about drug that can offer much-needed COVID-19 protection, and results showing scientists find new antibody treatments for COVID-19.
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