Scientists from Seoul National University Bundang Hospital found patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density.
They found people using insulin or sulfonylurea are at a high risk of fractures compared to metformin-only users, and the risk could be higher in non-obese and well-controlled diabetic patients.
The research was presented at ENDO 2022 and was conducted by Sung Hye Kong et al.
Anti-diabetic medications have long been suspected of an increased risk for fractures among this patient population.
In the study, the researchers included 6,694 patients aged ≥50 years from the common data model (CDM) database between 2008 and 2011, who used the same anti-diabetic medications for over a year.
They found that insulin users were at elevated risk of major osteoporotic and hip fracture compared to metformin users, which was reduced in users with a combination of insulin and metformin.
This increased fracture risk among people who used insulin was exaggerated among people who are not obese and those with well-controlled diabetes.
These findings suggest a need for routine fracture risk assessments in patients with diabetes.
If you care about diabetes, please read studies about best weight loss option for people with diabetes, and what is the normal blood sugar for people with diabetes.
For more information about diabetes, please see recent studies about which diabetes drugs can cause cancer, and results showing how to count carbs easily if you have diabetes.
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