Scientists from Mayo Clinic found an increased risk of dementia and depression in rheumatoid arthritis.
The research is published in presented at the 2022 EULAR Congress and was conducted by Dr. Jens Kristian Pedersen et al.
In the study, the team used data from the DANBIO registry to describe the death risk associated with depression in patients with rheumatoid arthritis (RA).
The group used the first filling of a prescription for antidepressants as a proxy for depression. Among 11,071 RA patients, 10% had filled prescriptions for antidepressants.
Analysis showed depression was linked to more than 6 times increased death risk in patients with incident RA.
Growing evidence suggests people with RA have a higher risk of developing dementia. However, the incidence of dementia among RA patients has declined in recent years.
The team found that RA, among other risk factors, is linked to a higher risk of dementia.
The cumulative incidence of dementia increased by 2–3% every 5 years after the diagnosis of RA, and older age at RA was consistently linked to the risk of dementia.
The presence of rheumatoid nodules, large joint swelling, hypertension, heart failure, and depression in RA incidence was strongly linked to the risk of dementia.
Large joint swelling, heart failure, ischemic stroke, anxiety, and depression at any time increased the risk of dementia.
The team says studies are ongoing to examine the role of inflammation and its interactions with other risk factors on the risk of cognitive decline in patients with RA.
If you care about dementia, please read studies about six ways to reboot your brain, and this drug may help treat Lewy body dementia.
For more information about mental health, please see recent studies about supplement that may help lower depression, and results showing this depression drug could shut down the brain.
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