Scientists from the University of Copenhagen found how high-intensity interval training (HIIT) could boost human skeletal muscles and reshape metabolism.
The findings suggest that HIIT boosts the amount of proteins in skeletal muscle that are essential for energy metabolism and muscle contraction, and chemically alters key metabolic proteins.
The research is published in eLife and was conducted by Morten Hostrup et al.
Exercising has many beneficial effects that can help prevent and treat metabolic diseases, and this is likely the result of changes in energy use by skeletal muscles.
In the study, the team wanted to understand how exercise alters the muscles’ protein content and how it regulates the activity of these proteins through a chemical reaction called acetylation.
They recruited eight healthy, untrained male volunteers to complete five weeks of high-intensity cycling training.
The men worked out three times per week, finishing four minutes of cycling at a target rate of more than 90% of their maximum heart rate followed by a two-minute rest.
They repeated this pattern four to five times per workout.
The team analyzed changes to the composition of 3,168 proteins in tissue samples collected from the participants’ thighs before the study and after they completed the training.
They found an increase in the production of proteins used to build mitochondria, which produce energy in cells, and in proteins related to muscle contractions.
The team also identified increased acetylation of mitochondrial proteins and enzymes that are involved in the production of cellular energy.
Additionally, they observed changes in the amount of proteins that reduce the skeletal muscle’s calcium sensitivity, which is essential for muscle contractions.
The results confirm some well-known changes to skeletal muscle proteins that occur after exercise, as well as identify new ones.
The work also suggests that exercise-induced changes in the regulation of proteins through acetylation may contribute to boosting metabolism.
If you care about metabolism, please read studies about these four ancient herbs may benefit your gut and metabolism and the findings of these things may determine your risk of metabolic syndrome.
For more information about metabolism, please see related studies about Yale scientists develop new drug to treat metabolic syndrome, and your metabolism changes as you age, but it is different from what you know.
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