In a new study from McMaster University, researchers found modifying red blood cells to transport viral agents which can safely trigger the immune system to protect the body against SARS-CoV-2.
Developing new strategies and vaccine technologies is critical for controlling the pandemic and preparing for future outbreaks as the coronavirus continues to evolve and mutate.
The new method is an entirely unique approach to vaccination.
Under the method, red-blood-cell membranes are embedded with SARS-CoV-2 spike proteins, which then form virus-like particles.
The particles, shown to activate the immune system and produce antibodies in mice, are completely harmless.
The researchers found cells can be loaded with a large dose of viral proteins, yet likely produce few side effects, making the new method more tolerable and effective than other vaccine options.
The technology can be quickly adapted to develop vaccines for variants or new viruses that may emerge in the future.
The researchers first reported this technique in 2020, when they modified red blood cells to deliver drugs throughout the body, which could then target infections or treat catastrophic diseases such as cancer or Alzheimer’s.
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The study is published in PLOS ONE and was conducted by Maikel Rheinstadter et al.
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