In a new study from Kaiser Permanente, researchers found that while Moderna COVID-19 vaccine protection is strong against coronavirus infection by the Delta variant, it is not as strong against infection from the Omicron variant.
But three doses of the Moderna COVID-19 vaccine were highly effective against hospitalization caused by the Omicron or Delta variant.
The study included 26,683 patients who tested positive for COVID-19, 16% of whom had Delta infections and 84% of whom had Omicron infections, and more than 67,000 individuals who tested negative as a comparison group.
The team found two doses of the Moderna COVID-19 vaccine were 44% effective against Omicron infection within 3 months after vaccination, and effectiveness quickly declined thereafter.
Three doses of the Moderna COVID-19 vaccine within 2 months of vaccination were 94% effective against Delta infection and 72% effective against Omicron infection.
For people who had compromised immune systems, 3-dose effectiveness against Omicron infection was lower at 29%.
The 3-dose effectiveness against hospitalization with Delta or with Omicron was above 99%.
The results suggest that third doses may be needed sooner than 6 months after the second dose of the Moderna COVID-19 vaccine to protect against Omicron infection.
And that 3 doses may be inadequate to protect people who are immunocompromised from Omicron infection.
If you care about COVID, please read studies about drug that could lower death risk caused by COVID-19, and who has the highest risk of heart damage in COVID-19.
For more information about health, please see recent studies about drug that could reduce obesity, fatty liver, improve heart function, and results showing that Omicron may be less likely to cause severe disease.
The study is published in Nature Medicine and was conducted by Hung Fu Tseng et al.
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