In a recent study published in Scientific Reports, researchers found how hormone relaxin interacts with the body’s signaling processes to produce a fundamental mechanism that may improve heart disease treatment.
The study is from the University of Pittsburgh. One author is Brian Martin.
As a healthy heart ages, it becomes more susceptible to cardiovascular diseases.
Though researchers have discovered that relaxin, an insulin-like hormone, suppresses atrial fibrillation (AF), inflammation, and fibrosis, the underlying mechanisms of these benefits are still unknown.
Relaxin is a reproductive hormone discovered in the early 20th century that has been shown to suppress heart disease symptoms
In this study, the team found that relaxin treatment reverses electrical remodeling in animal models by activating canonical Wnt signaling—a discovery that reveals a fundamental underlying mechanism behind relaxin’s benefits.
A better understanding of how relaxin interacts with the body may improve its efficacy as a therapy to treat heart disease in humans.
A common problem in age-associated heart disease is altered electrical signaling required for proper heart contraction.
When ions in the heart and their associated channels enter or exit the heart are disrupted, complications occur.
Natural, healthy aging has been shown to be accompanied by changes in structure and function.
The reversal of some aspects of the aging process by relaxin is mediated by the reactivation of Wnt canonical signaling which may partly explain mechanisms of the aging process.
The team found increased prominent sodium channel, Nav1.5, in cells of the heart tissue may lead to better electrical signaling in the heart and may reduce susceptibility to cardiac rhythm disorders.
While these data provide new insight into relaxin’s mechanisms of action, further work is needed to understand the precise steps required for relaxin to alter Wnt signaling.
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