In a new study from Erasmus MC University, researchers found that patients with stroke have steeper declines in cognition and daily functioning up to 10 years before an incident stroke.
In the study, the team examined cognition and functional activities of daily living among 14,712 participants within the Rotterdam Study between 1990 and 2016. Medical records were monitored until 2018 to assess incident stroke.
The trajectories of cognition and daily functioning were examined for 10 years before and after stroke.
The researchers found that 1,662 participants had a first-ever stroke during a follow-up of 12.5 years.
In terms of cognition and daily functioning, people who had a stroke different from stroke-free people up to 10 years before stroke diagnosis.
Before the stroke, there were strong differences in cognitive and functional abilities.
The findings demonstrated that future stroke patients start to deviate from stroke-free people up to 10 years before the stroke happens.
This suggests that individuals with cognitive and functional decline are at a higher risk of stroke.
The accelerated decline in cognition and daily functioning before stroke suggests that people with future stroke suffer from accumulating brain damage years before the stroke, such as cerebral small vessel disease, neurodegeneration, and inflammation.”
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The study is published in the Journal of Neurology, Neurosurgery & Psychiatry. One author of the study is Alis Heshmatollah.
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