Cannabis may be linked to development of opioid use disorders

Credit: CC0 Public Domain

The idea that cannabis is a ‘gateway drug’ to more harmful substances such as opioids is controversial, yet has substantially impacted drug policy, education and how we conceptualize substance use.

In a new study from the University of Sydney, researchers found that people who use cannabis are much more likely to initiate opioid use and engage in problematic patterns of use than people who do not use cannabis.

One surprising discovery in this study was that there aren’t many good studies on the gateway drug theory.

Despite the frequency with which the topic of gateway drugs is discussed, only six studies were of high enough quality to include.

A synthesis of the evidence from those six studies showed that people who use cannabis are more than twice as likely to initiate opioid use and develop problematic patterns of use as people who don’t use cannabis.

But the quality of the evidence in those studies is low and must be interpreted with caution.

All six studies had a moderate risk of bias and overlooked important confounding variables such as cannabis use frequency and affiliation with cannabis or opioid-using peers.

It is unclear whether these unmeasured variables would have had a strong enough impact to explain away the cannabis-opioid use link.

It is therefore not possible, on the existing evidence, to state conclusively that there is a causal relationship between cannabis and subsequent opioid use, but it is likely that there is at least a partial causal relationship.

The six studies provided data from the United States, Australia and New Zealand between 1977 and 2017, with a total sample of 102,461 participants.

If you care about cannabis and your health, please read studies about people with this heart problem need to use cannabis cautiously and findings of smoking cannabis may strongly impairs your eyes.

For more information about cannabis and wellness, please see recent studies about early cannabis use linked to heart disease and results showing that medical cannabis can reduce this brain disorder.

The study is published in Addiction. One author of the study is Jack Wilson.

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