In a new study from the University of Reading, researchers found that people who are genetically more likely to suffer from heart diseases may benefit from boosting a biomarker found in fish oils.
They found the first evidence for the role of adiponectin, an obesity-related biomarker, in the association between a genetic variation called omentin and cardio-metabolic health.
In the study, the team examined 1,886 Asian Indians. These participants had a particular genetic risk of developing heart disease.
These people were found to have a strong link between low levels of adiponectin and heart disease, even after adjusting for factors normally linked with heart disease.
This suggests the role of adiponectin in heart disease and it is independent of obesity.
This is an important insight into one way that people who are not obese may develop heart disease, through low concentrations of a biomarker in the body called adiponectin.
Further analysis showed that those with genetic variation in omentin production also had less of the biomarker adiponectin in their body.
The team says the findings demonstrate why certain lifestyle factors such as consumption of oily fish and regular exercise are so important for warding off the risk of heart disease.
The omentin gene itself works to produce a protein in the body that has been shown to have anti-inflammatory and heart-protective effects, and variations in the omentin gene have previously linked to cardio-metabolic diseases.
The findings suggest that people can develop cardio-metabolic diseases due to this specific omentin genetic risk if they have low levels of the biomarker adiponectin.
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The study is published in PLOS ONE. One author of the study is Professor Vimal Karani.
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